This guide provides guidance on how to integrate GESI in design, implementation, monitoring, and evaluation of health programs. This will ensure that health programming transforms the lives of all women, men, girls and boys regardless of age, disability, ethnicity, religion or any other social characteristics. and that all vulnerable groups are meaningfully engaged in the transformation of their lives. This guide will also help to understand ways to make informal and formal health systems and interventions more equal and inclusive by design and delivery.